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| Seth Rogen | B.O.B. | |
| Reese Witherspoon | Susan Murphy / Ginormica | |
| Hugh Laurie | Dr. Cockroach Ph.D. | |
| Paul Rudd | Derek | |
| Kiefer Sutherland | General W.R. Monger | |
| Rainn Wilson | Gallaxhar | |
| Will Arnett | The Missing Link | |
| Stephen Colbert | The President of the United States | |
| Julie White | Wendy Murphy | |
| Jeffrey Tambor | Carl Murphy | |
| Amy Poehler | Computer | |
| Ed Helms | News Reporter | |
| Renée Zellweger | Katie | |
| John Krasinski | Cuthbert | |
| Sean Bishop | Private Bullhorn / Helicopter Pilot / Advisor Ortega |
| Director | Conrad Vernon
Rob Letterman |
| Producer | Lisa Stewart
Jill Hopper |
| Writer | Wallace Wolodarsky
Conrad Vernon |
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When Susan Murphy is unwittingly clobbered by a meteor full of outer space gunk on her wedding day, she mysteriously grows to 49-feet-11-inches. The military jumps into action and captures Susan, secreting her away to a covert government compound. She is renamed Ginormica and placed in confinement with a ragtag group of Monsters... |
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